Position: Affiliated Assistant Professor

MAIL: kshirakw [at]

Research Departments

Global Humanosphere


Protozoan infectious disease, Theoretical Epidemiology, Medical Statistics, Systems Biology, Structural Biology

Research Interests

・Introduction of new theoretical epidemiology and medical statistical method in regional specificity research of malaria
・Structural biological study on occurrence of drug resistant type malaria
・Factor analysis affecting the convergence of infectious diseases

Introduction of new theoretical epidemiology and medical statistical method in regional specificity research of malaria
The incidence of malaria patients in Sarawak, Malaysia is less than that of malaria in adjacent Indonesia, but about 3000 cases of infectious cases have been reported annually and about 15 people have died. In this study, we analyzed the relationship between changes in the dynamics of malaria patients and various region-specific factors, including climate and race, and examined the preventive method which can be judged effective from the viewpoint of medical economics and medical policy . The applicant has already carried out research focusing on accumulation in epidemiological research related to the subject matter. In this study, considering confounding factors related to region specificity, by introducing a econometric analysis method into conventional epidemiological research, It is possible to introduce analysis of spatiotemporal level which has not yet been implemented in the research field of epidemic infectious diseases.

Structural biological study on occurrence of drug resistant type malaria
In border area of Southeast Asian , placement and use of placebo frequently occurred, which caused death of malaria patients and resistant type malaria occurred due to the use of placebo. In this study, in addition to the study of 1), we investigated by molecular epidemiological method that placebo is involved in the development and diffusion of drug resistant protozoa by flowing into economically poor residents, we clarify that the components contribute to occurrence of resistant malaria.

Factor analysis affecting the convergence of infectious diseases
For infectious diseases that have disappeared in the past, search for factors related to extinction using Markov chain Monte Carlo methods (MCMC) and perform time series analysis of existing infectious diseases.

  • 1)Koichi Shirakawa, Patrick Guda Benjamin, Son Radu, Mitsuaki Nishibuchi, Caution on use of anti-malaria drug for control of mixed infection of malaria: Bayesian analysis of malaria data from Sarawak, Malaysia, Parasitic Zoonoses in Asia-Pacific Regions 2012 , pp.25-28 2013年 ISBN978-4-86487-094-8
  • 2)Koichi Shirakawa, Mitsuaki Nishibuchi, The 8th European Congress on Tropical Medicine and International Health & 5th Conference of the Scandinavian-Baltic Society for Parasitology, 10-13 September 2013, Copenhagen, DenmarkTropical Medicine & International Health 18 144
  • 3) Koichi Shirakawa , epidemiology and mathematical biology of malaria and mathematical biology, Can not eradicate malaria? Japan Mathematical Biology Society Newsletter, No. 70, pp. 22-24 May 2013 (Epidemiology and mathematical biology method of malaria. combat malaria. Japan Mathematical Biological Society newsletter)
  • 4) Koichi Shirakawa, Gaku Masuda, Noboru Ishikawa, Mitsuaki Nishibuchi, Control model for malaria-borne mosquitoes in Malaysia, Kuching, Medical Entomology and Zoology 61 p.52, 2010 (The control model for the mosquitoes that mediates malaria in Kuching , Malaysia)
  • 5) Koichi Shirakawa, Mediation of mosquitoes (genus Anopheles) and theoretical epidemiology of malaria infection, the 6th biological mathematical theory and its application RIMS research meeting meeting Report Kyoto University Mathematical Analysis Laboratory lecture volume 1704 31-36 2010 Year (Ecological Mechanism Anopheles mediates the Plasmodium spp. And the theoretical epidemiology of malaria infection)
  • 6) Koichi Shirakawa, Mitsuaki Nishibuchi, Characteristics of malaria in various areas of Sarawak, Malaysia caught from prevalence clustering – prevalence clustering in Sarawak, Malaysia, characteristics of malaria in various regions of Sarawak, Malaysia caught from the occurrence rate of clustering, clustering rate in Sarawak, Malaysia, Abstracts of Japan Tropical Medicine Association Abstracts Collection, No. 53, 75-76, 2012

  • On the occurrence and transmission of infectious disease patients in major transportation facilities, The University of Tokyo, Spatial Information Science Center Collaborative Research
    “Factor analysis and control of development of drug-resistant malaria”, Second symposium sponsored by Kyoto University Microbiological Science Donation Research Division “Diversity and New Development of Microbial Science Research”

  • 1)Japan Mathematical Biology Society · Kyoto University Mathematical Analysis Laboratory Hosted Mathematical
    Model Contest Best Prize Jointly Received
  • 2)Won Graduate School of Medicine , KyotoUniversity, Dispatch International Awards (UK)